Recommended Form
Follow label directions — standardized extract
When to Take
30-60 minutes before bed
Bryan Johnson Uses
No
What is Apigenin?
Apigenin is a flavonoid found in chamomile that produces calming effects by binding to benzodiazepine receptors without the side effects of actual benzodiazepines. It's a natural anxiolytic and sleep aid.
How Apigenin Works for Sleep
Apigenin binds to GABA-A receptors (specifically the benzodiazepine binding site), reducing anxiety and promoting relaxation. Unlike benzodiazepines, it doesn't cause dependence, tolerance, or cognitive impairment.
Benefits for Sleep
What the Research Says
Apigenin gained popularity after Andrew Huberman discussed it. It's the main active compound in chamomile responsible for its calming effects. Studies show anxiolytic effects comparable to low-dose benzodiazepines without the side effects. The research-backed dose is derived from the amount in strong chamomile tea.
Possible Side Effects
- !Generally very well tolerated
- !Possible sedation in sensitive individuals
- !Theoretical testosterone concerns at very high doses (not seen at typical amounts)
Interactions
- iMay enhance sedative medications
- iCould potentially interact with CYP enzymes
- iGenerally safe profile
- iOK to combine with magnesium and glycine
How to Choose Quality Apigenin
- 1Look for standardized chamomile extract
- 2Use a standardized extract
- 3Can combine with magnesium and glycine
- 4Swanson and NOW Foods make quality versions
- 5Alternative: very strong chamomile tea (3-4 bags)