Recommended Form
Follow label directions — PharmaGABA form preferred
When to Take
30-60 minutes before bed
Bryan Johnson Uses
No
What is GABA?
GABA is the main inhibitory neurotransmitter in the brain. While supplemental GABA's ability to cross the blood-brain barrier is debated, many users report calming effects, possibly through the gut-brain axis.
How GABA Works for Sleep
GABA reduces neuronal excitability throughout the nervous system. Supplemental GABA may work through gut GABA receptors affecting the vagus nerve, or small amounts may cross the blood-brain barrier. Pharma-GABA is a naturally-produced form with better absorption.
Benefits for Sleep
What the Research Says
Research on GABA supplements is mixed due to blood-brain barrier questions. However, PharmaGABA (naturally fermented) shows better results in studies, reducing anxiety and improving sleep quality. A 2016 study found GABA improved sleep quality in those with poor sleep. Effects may be partly mediated through gut-brain signaling.
Possible Side Effects
- !Generally well tolerated
- !Possible tingling or flushing
- !May cause temporary shortness of breath
Interactions
- iMay enhance sedative medications
- iCaution with blood pressure medications
- iAvoid with alcohol
How to Choose Quality GABA
- 1PharmaGABA is the preferred form
- 2Synthetic GABA requires higher doses
- 3Can combine with L-theanine
- 4Start with lower doses
- 5Take on empty stomach for best absorption